Function of ADH
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The most important renal action of Anti Diuretic Hormone or ADH is to increase the water permeability of the collecting duct epithelia of the nephron and thus controlling the degree of dilution or concentration of the urine. When the body needs to conserve water in circumstances such as dehydration ADH is secreted in the circulation. ADH binds to specific V2 receptors in the basolateral membrane of collecting duct epithelial cells. This, in turn, increases the formation of second messenger cyclic AMP. cAMP activates protein kinase A by phosphorylation. Activated PKA stimulates the movement of storage vesicle with intracellular protein, called aquaporin-2 (AQP-2), to the luminal side of the cell membranes. The molecules of AQP-2 fuse with the cell membrane by exocytosis to form water channels that permit rapid diffusion of water through the cells.
Other aquaporins, AQP-3 and AQP-4, in the basolateral side of the cell membrane provide a path
for water to rapidly exit the cells. Although these are not believed to be regulated by ADH.
When the concentration of ADH decreases, the molecules of AQP-2 are shuttled back to the cell cytoplasm, thereby removing the water channels from the luminal membrane.
4 سال پیش
در تاریخ 1399/02/10 منتشر شده
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