The Advanced Pathophysiology of Insulin Resistance, Metabolic Syndrome, and Cardiovascular Disease

Hypertrophic adipose tissue — ectopic lipid -- lpl modification — higher residence time -- oxLDL
LDLr -- liver lipid turnover — Gluconeogensis?
Subcutaneous hypertrophy — macrophage THF-alpha & IL-6 & Lipolysis NEFA— DAG in liver — PKC epsilon in liver, PKC theta in muscle
Iron -- Pancreas?

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