Azithromycin Mechanism of Action
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Azithromycin Mechanism of Action.Like other
Azithromycin Mechanism of Action.
Like other macrolide antimicrobials, azithromycin binds to the 23S portion of the 50S bacterial ribosomal subunit. It inhibits bacterial protein synthesis by preventing the transit of aminoacyl-tRNA and the growing protein through the ribosome. Compared to erythromycin, azithromycin is less prone to disassociation from the gram-negative ribosome, conferring its greater efficacy against gram-negative pathogens. Like other macrolides and protein-synthesis inhibitors, azithromycin primarily acts as a bacteriostatic agent, meaning it inhibits bacterial growth rather than directly killing organisms. However, especially at higher doses, azithromycin has been shown to have a bactericidal effect against certain bacteria, such as streptococci and H. influenzae.
Pharmacokinetically, azithromycin rapidly moves from the bloodstream into tissues and, once there, readily crosses cellular membranes, allowing efficacy against intracellular pathogens. In non-bacterial organisms like Babesia sp., Plasmodium sp., and Toxoplasma sp., azithromycin stops the 50S ribosome from working in the parasite apicoplast. The apicoplast is an endosymbiotic organelle that has bacteria-like protein-synthesis machinery that is important for metabolism.
In addition to azithromycin’s antimicrobial activity, it is also a potent immunomodulator that has been shown to markedly reduce airway neutrophilia, IL-8 gene expression, and C-reactive protein levels in lung transplant recipients. Azithromycin has in vitro antiviral properties, which has created interest in the experimental treatment of SARS-CoV-2. by increasing the production of RIG-I-like helicases, azithromycin improved the production of interferons caused by rhinoviruses in COPD cell cultures but not in healthy cell cultures.
Summary
Azithromycin is a macrolide antibiotic that binds to the 23S part of the 50S bacterial ribosomal subunit. This stops the production of proteins by bacteria by blocking the movement of aminoacyl-tRNA. It primarily acts as a bacteriostatic agent, inhibiting bacterial growth but having bactericidal effects against certain bacteria. Azithromycin also changes the immune system by lowering the number of neutrophils in the airways, the expression of the IL-8 gene, and the levels of C-reactive protein in people who have had lung transplants. Its in vitro antiviral properties have led to interest in treating SARS-CoV-2.
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Like other macrolide antimicrobials, azithromycin binds to the 23S portion of the 50S bacterial ribosomal subunit. It inhibits bacterial protein synthesis by preventing the transit of aminoacyl-tRNA and the growing protein through the ribosome. Compared to erythromycin, azithromycin is less prone to disassociation from the gram-negative ribosome, conferring its greater efficacy against gram-negative pathogens. Like other macrolides and protein-synthesis inhibitors, azithromycin primarily acts as a bacteriostatic agent, meaning it inhibits bacterial growth rather than directly killing organisms. However, especially at higher doses, azithromycin has been shown to have a bactericidal effect against certain bacteria, such as streptococci and H. influenzae.
Pharmacokinetically, azithromycin rapidly moves from the bloodstream into tissues and, once there, readily crosses cellular membranes, allowing efficacy against intracellular pathogens. In non-bacterial organisms like Babesia sp., Plasmodium sp., and Toxoplasma sp., azithromycin stops the 50S ribosome from working in the parasite apicoplast. The apicoplast is an endosymbiotic organelle that has bacteria-like protein-synthesis machinery that is important for metabolism.
In addition to azithromycin’s antimicrobial activity, it is also a potent immunomodulator that has been shown to markedly reduce airway neutrophilia, IL-8 gene expression, and C-reactive protein levels in lung transplant recipients. Azithromycin has in vitro antiviral properties, which has created interest in the experimental treatment of SARS-CoV-2. by increasing the production of RIG-I-like helicases, azithromycin improved the production of interferons caused by rhinoviruses in COPD cell cultures but not in healthy cell cultures.
Summary
Azithromycin is a macrolide antibiotic that binds to the 23S part of the 50S bacterial ribosomal subunit. This stops the production of proteins by bacteria by blocking the movement of aminoacyl-tRNA. It primarily acts as a bacteriostatic agent, inhibiting bacterial growth but having bactericidal effects against certain bacteria. Azithromycin also changes the immune system by lowering the number of neutrophils in the airways, the expression of the IL-8 gene, and the levels of C-reactive protein in people who have had lung transplants. Its in vitro antiviral properties have led to interest in treating SARS-CoV-2.
Thank you for watching!
👍 This content is mainly for the purpose of learning English vocabulary 👌, English grammar, and English sentence structure!
We are learning American English!
Thank you for taking the time to watch!
Thank you for considering subscribing to see more exciting videos!
7 ماه پیش
در تاریخ 1402/09/29 منتشر شده
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