Webinar - Automated IR-Spectroscopy for Analysis of Protein Biopharmaceuticals RedShiftBio - Pfizer

Protein higher-order structure is an important product quality attribute that governs the structure-function characteristics, safety, and efficacy of therapeutic proteins. Infrared (IR) spectroscopy has long been recognized as a powerful biophysical tool in determining protein secondary structure and monitoring dynamic structural changes. Such biophysics analyses help establish process and product knowledge, understand the impact of upstream (cell culture) and downstream (purification) process conditions, create stable formulations, monitor product stability, and assess product comparability when process improvements are implemented (or establish biosimilarity to originator products)

In this webinar, Dr. Lucy Liu will provide an overview of a novel automated
mid-IR spectroscopic technique called microfluidic modulation IR spectroscopy (MMS or MM-IR) for the characterization of protein secondary structure. This data demonstrates that MM-IR secondary structure analysis of therapeutic monoclonal antibodies (mAb) is comparable with a conventional Fourier transform IR (FTIR) method. More importantly, Dr. Liu’s work shows that MM-IR exhibits higher sensitivity and repeatability for low concentration samples over FTIR and provides automated operation and
superior robustness with simplified data analysis, increasing the instrument’s utility in the determination of mAb secondary structure. All of this, leading to the idea that the MM-IR method can be widely applied in characterization and comparability.

For more information, visit us at https://www.redshiftbio.com/