A Neuroinflammatory Model for ME/CFS (a hypothesis)
795 بار بازدید -
5 ماه پیش
-
Dr Angus Mackay talks with
Dr Angus Mackay talks with us about his theory that neuroinflammation is the cause of ME/CFS (and Long Covid related post-viral fatigue syndrome).
Presentation for MECFS Canterbury, 14th February 2024.
Angus hopes that as brain imaging techniques develop, the model will be used by researchers to explore and develop a better understanding of this debilitating disease.
The model revolves around a dysfunctional and inflamed hypothalamus, the master gland within the brain, and the stress-response centre within it, called the paraventricular nucleus (PVN), that responds to all significant stressors including viral and other shocks.
____________________________
ADDITIONAL RESOURCES:
✦ Timestamped slide list further below
✦ Pdf of the slide deck - https://drive.google.com/file/d/1Hxjj...
✦ Biography and Outline of presentation https://drive.google.com/file/d/1QNyO...
✦ The published papers on the theory:
- Mackay, A. (2021). A Paradigm for Post-Covid-19 Fatigue Syndrome Analogous to ME/CFS. Frontiers in neurology, 12, 701419-701419. https://doi.org/10.3389/fneur.2021.70...
- Mackay, A. (2019). A neuro-inflammatory model can explain the onset, symptoms and flare-ups of myalgic encephalomyelitis/chronic fatigue syndrome. Journal of primary health care, 11(4), 300-307. https://doi.org/10.1071/HC19041
- Mackay, A., & Tate, W. P. (2018). A compromised paraventricular nucleus within a dysfunctional hypothalamus: A novel neuroinflammatory paradigm for ME/CFS. International journal of immunopathology and pharmacology, 32, 205873841881234. https://doi.org/10.1177/2058738418812342
____________________________
CONTENT /SLIDE LIST:
00:00 Introduction
.
02:54 An analogy of ME/CFS - the two jars
.
05:31 Presentation topic: A Neuroinflammatory Model for ME/CFS
06:02 A Personal Journey – Gaining insight into ME/CFS
.
08:46 Why has Neuroinflammatory Hypothesis for ME/CFS been slow to take off?
- Neuorinflammation in ME/CFS brains chronic but at a low-level
- Brain does not contain nociceptors (pain/ heat receptors)
- The red herrings
15:57 The Hypothalamus (master gland) is Key
18:55 Hypothalamic Paraventricular Nucleus (PVN) - Eureka!!
20:38 Possible Triggering Mechanism of ME/CFS
23:20 Glial-cells (brain /Central Nervous System immune cells)
27:01 Increasing Evidence of Neuroinflammation in ME/CFS
32:48 ME/CFS Symptoms (Explanation of)
36:04 PEM (Post-exertional malaise), Flares and Relapses
42:21 Stressors and Paraventricular Nucleus (PVN)
45:16 PVN is same target for Triggering Stressors and Perpetuating Stressors of ME/CFS
.
45:49 A Neuroinflammatory Model for ME/CFS
.
49:59 The Long COVID Conundrum
52:30 Possible triggering mechanism for Long-COVID related ME/CFS
53:39 Evidence of Neuroinflammation in Long-COVID
54:29 Further Evidence of Neuroinflammation in Long-COVID (ME/CFS)
55:30 A Neuroinflammatory Model for ME/CFS applicable to Long-COVID related ME/CFS
.
55:56 Future Needs
1:00:53 Pacing How to Pace Yourself with ME/CFS (or Fibromyalgia or Long-COVID related ME/CFS)
- Avoid unnecessary stressors
- Listen to your body
- Manage your symptoms
.
1:03:04 The Papers Related to this Model
- Mackay, A. (2021). A Paradigm for Post-Covid-19 Fatigue Syndrome Analogous to ME/CFS. Frontiers in neurology, 12, 701419-701419. https://doi.org/10.3389/fneur.2021.70...
- Mackay, A. (2019). A neuro-inflammatory model can explain the onset, symptoms and flare-ups of myalgic encephalomyelitis/chronic fatigue syndrome. Journal of primary health care, 11(4), 300-307. https://doi.org/10.1071/HC19041
- Mackay, A., & Tate, W. P. (2018). A compromised paraventricular nucleus within a dysfunctional hypothalamus: A novel neuroinflammatory paradigm for ME/CFS. International journal of immunopathology and pharmacology, 32, 205873841881234. https://doi.org/10.1177/2058738418812342
.
1:03:44 Questions
1:03:59 Is it a genetic susceptibility or does this susceptibility change over time? As many people report coping with many stressors, and then something similar happens that then triggers ME/CFS.
1:06:40 Example shared of a recent relapse caused by exposure to more sunlight when blinds were removed for cleaning.
1:08:27 Angus’s connection dropped out
1:08:33 How did people find the talk?
1:10:10 Angus returns
1:10:30 Does this model resonate with people?
- Eye pain; feeling of a swollen head.
1:13:35 Thank you Angus
1:15:18 We need researchers to explore and validate the model now
.
1:16:42 Thank you to the funders of MECFS Canterbury
Presentation for MECFS Canterbury, 14th February 2024.
Angus hopes that as brain imaging techniques develop, the model will be used by researchers to explore and develop a better understanding of this debilitating disease.
The model revolves around a dysfunctional and inflamed hypothalamus, the master gland within the brain, and the stress-response centre within it, called the paraventricular nucleus (PVN), that responds to all significant stressors including viral and other shocks.
____________________________
ADDITIONAL RESOURCES:
✦ Timestamped slide list further below
✦ Pdf of the slide deck - https://drive.google.com/file/d/1Hxjj...
✦ Biography and Outline of presentation https://drive.google.com/file/d/1QNyO...
✦ The published papers on the theory:
- Mackay, A. (2021). A Paradigm for Post-Covid-19 Fatigue Syndrome Analogous to ME/CFS. Frontiers in neurology, 12, 701419-701419. https://doi.org/10.3389/fneur.2021.70...
- Mackay, A. (2019). A neuro-inflammatory model can explain the onset, symptoms and flare-ups of myalgic encephalomyelitis/chronic fatigue syndrome. Journal of primary health care, 11(4), 300-307. https://doi.org/10.1071/HC19041
- Mackay, A., & Tate, W. P. (2018). A compromised paraventricular nucleus within a dysfunctional hypothalamus: A novel neuroinflammatory paradigm for ME/CFS. International journal of immunopathology and pharmacology, 32, 205873841881234. https://doi.org/10.1177/2058738418812342
____________________________
CONTENT /SLIDE LIST:
00:00 Introduction
.
02:54 An analogy of ME/CFS - the two jars
.
05:31 Presentation topic: A Neuroinflammatory Model for ME/CFS
06:02 A Personal Journey – Gaining insight into ME/CFS
.
08:46 Why has Neuroinflammatory Hypothesis for ME/CFS been slow to take off?
- Neuorinflammation in ME/CFS brains chronic but at a low-level
- Brain does not contain nociceptors (pain/ heat receptors)
- The red herrings
15:57 The Hypothalamus (master gland) is Key
18:55 Hypothalamic Paraventricular Nucleus (PVN) - Eureka!!
20:38 Possible Triggering Mechanism of ME/CFS
23:20 Glial-cells (brain /Central Nervous System immune cells)
27:01 Increasing Evidence of Neuroinflammation in ME/CFS
32:48 ME/CFS Symptoms (Explanation of)
36:04 PEM (Post-exertional malaise), Flares and Relapses
42:21 Stressors and Paraventricular Nucleus (PVN)
45:16 PVN is same target for Triggering Stressors and Perpetuating Stressors of ME/CFS
.
45:49 A Neuroinflammatory Model for ME/CFS
.
49:59 The Long COVID Conundrum
52:30 Possible triggering mechanism for Long-COVID related ME/CFS
53:39 Evidence of Neuroinflammation in Long-COVID
54:29 Further Evidence of Neuroinflammation in Long-COVID (ME/CFS)
55:30 A Neuroinflammatory Model for ME/CFS applicable to Long-COVID related ME/CFS
.
55:56 Future Needs
1:00:53 Pacing How to Pace Yourself with ME/CFS (or Fibromyalgia or Long-COVID related ME/CFS)
- Avoid unnecessary stressors
- Listen to your body
- Manage your symptoms
.
1:03:04 The Papers Related to this Model
- Mackay, A. (2021). A Paradigm for Post-Covid-19 Fatigue Syndrome Analogous to ME/CFS. Frontiers in neurology, 12, 701419-701419. https://doi.org/10.3389/fneur.2021.70...
- Mackay, A. (2019). A neuro-inflammatory model can explain the onset, symptoms and flare-ups of myalgic encephalomyelitis/chronic fatigue syndrome. Journal of primary health care, 11(4), 300-307. https://doi.org/10.1071/HC19041
- Mackay, A., & Tate, W. P. (2018). A compromised paraventricular nucleus within a dysfunctional hypothalamus: A novel neuroinflammatory paradigm for ME/CFS. International journal of immunopathology and pharmacology, 32, 205873841881234. https://doi.org/10.1177/2058738418812342
.
1:03:44 Questions
1:03:59 Is it a genetic susceptibility or does this susceptibility change over time? As many people report coping with many stressors, and then something similar happens that then triggers ME/CFS.
1:06:40 Example shared of a recent relapse caused by exposure to more sunlight when blinds were removed for cleaning.
1:08:27 Angus’s connection dropped out
1:08:33 How did people find the talk?
1:10:10 Angus returns
1:10:30 Does this model resonate with people?
- Eye pain; feeling of a swollen head.
1:13:35 Thank you Angus
1:15:18 We need researchers to explore and validate the model now
.
1:16:42 Thank you to the funders of MECFS Canterbury
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