Managing Side Effects of Chemotherapy | Prostate Cancer Staging Guide
6.4 هزار بار بازدید -
5 سال پیش
-
PCRI’s Executive Director, Mark Scholz,
PCRI’s Executive Director, Mark Scholz, MD, discusses the advantages of chemotherapy for men with High-Indigo (or relapsed prostate cancer with known pelvic lymph node involvement) and offers ways to manage its side effects.
0:16 Chemotherapy is rare in prostate cancer treatment due to the effectiveness of hormone therapy, but studies have shown that chemotherapy can improve cure rates and survival in men with advanced metastatic disease. This video is concerned with High-Indigo stage prostate cancer (i.e. relapsed prostate cancer with known lymph-node involvement).
1:16 Fatigue is a common side effect of chemotherapy and it is often made worse by fatigue from coinciding hormone therapy. The best thing men can do to manage this side effect is to exercise regularly. Even if the fatigue is too intense for vigorous exercise, men should do as much as they can to stay active and move their bodies.
2:15 Fatigue can also be addressed by modifying dosages. Typically Taxotere is given every three weeks, however, it can be given in smaller doses weekly with fewer side effects. Another approach would be to reduce the number of cycles of Taxotere. Studies show the optimal number of cycles is six, but most of the side effects occur in cycles 4-6 and most of the benefits occur in cycles 1-4. Reducing the number of cycles to four may reduce the cure rate, but it will also significantly reduce the side effects.
3:40 Many doctors use Cortisone with Prednisone, 5-10mg per day, as a treatment for fatigue, and it does have benefits, but it also has its own set of risks. Another pharmaceutical agent to consider is Provigil (modafinil) which is like a stimulant and can counteract fatigue at a dose of 100-200mg per day.
4:23 Another approach is to change the type of chemotherapy from Taxotere to Jevtana (cabazitaxel).
5:00 Nausea used to be a concern with chemotherapy, but now pharmaceuticals such as Zofran have almost totally eliminated it as a concern.
5:32 Hair loss occurs in about 50% of people undergoing chemotherapy. It is reversible, but people who want to avoid it altogether can use newly developed ice caps that shunt blood flow from the head. They are not FDA approved, not covered by insurance, and so may be expensive.
6:24 Low Blood Count is a side effect of chemotherapy that can put a patient at risk of infection, and it can be prevented with an injection called Neulasta or Neupogen. It may be worth asking your physician to use it concurrently with the chemo to prevent infection.
7:05 Damage to the taste buds can be counteracted by putting ice in your mouth during the administration of the chemotherapy to shunt blood away from the taste buds. The same principle can be applied by putting your fingers on ice to help prevent fingernail damage.
7:58 A problem that is more common with weekly applications of Taxotere is that the drug can cause damage to the tear ducts. In serious cases, even scarring or closing of the tear ducts can occur. If someone undergoing chemotherapy notices increasing tearing then they need to see an eye doctor who can put a tube into the tear ducts that will allow normal drainage to occur. Ignoring this problem can cause the scarring to be permanent.
8:55 The use of chemotherapy is becoming more popular now that studies have shown that it can effectively treat High-Indigo stage (or relapsed) prostate cancer. With proper management, the side effects of chemotherapy can usually be eliminated or at least minimized to be made tolerable.
Don’t know your stage? Take the quiz: Visit http://www.prostatecancerstaging.org
To learn more about prostate cancer visit http://www.pcri.org
To download the free Staging Guide visit http://www.pcri.org/prostate-cancer-s...
Who we are:
The Prostate Cancer Research Institute (PCRI) is a 501(c)(3) not-for-profit organization that is dedicated to helping you research your treatment options. We understand that you have many questions, and we can help you find the answers that are specific to your case. All of our resources are designed by a multidisciplinary team of advocates and expert physicians, for patients. We believe that by educating yourself about the disease, you will have more productive interactions with your medical professionals and receive better-individualized care. Feel free to explore our website or call our free helpline at 1 (800) 641-7274 with any questions that you have. Our Federal Tax ID # is 95-4617875 and qualifies for maximum charitable gift deductions by individual donors.
The information on the Prostate Cancer Research Institute's YouTube channel is provided with the understanding that the Institute is not engaged in rendering medical advice or recommendation. The information provided in these videos should not replace consultations with qualified health care professionals to meet your individual medical needs.
#ProstateCancer #Prostate #MarkScholzMD
0:16 Chemotherapy is rare in prostate cancer treatment due to the effectiveness of hormone therapy, but studies have shown that chemotherapy can improve cure rates and survival in men with advanced metastatic disease. This video is concerned with High-Indigo stage prostate cancer (i.e. relapsed prostate cancer with known lymph-node involvement).
1:16 Fatigue is a common side effect of chemotherapy and it is often made worse by fatigue from coinciding hormone therapy. The best thing men can do to manage this side effect is to exercise regularly. Even if the fatigue is too intense for vigorous exercise, men should do as much as they can to stay active and move their bodies.
2:15 Fatigue can also be addressed by modifying dosages. Typically Taxotere is given every three weeks, however, it can be given in smaller doses weekly with fewer side effects. Another approach would be to reduce the number of cycles of Taxotere. Studies show the optimal number of cycles is six, but most of the side effects occur in cycles 4-6 and most of the benefits occur in cycles 1-4. Reducing the number of cycles to four may reduce the cure rate, but it will also significantly reduce the side effects.
3:40 Many doctors use Cortisone with Prednisone, 5-10mg per day, as a treatment for fatigue, and it does have benefits, but it also has its own set of risks. Another pharmaceutical agent to consider is Provigil (modafinil) which is like a stimulant and can counteract fatigue at a dose of 100-200mg per day.
4:23 Another approach is to change the type of chemotherapy from Taxotere to Jevtana (cabazitaxel).
5:00 Nausea used to be a concern with chemotherapy, but now pharmaceuticals such as Zofran have almost totally eliminated it as a concern.
5:32 Hair loss occurs in about 50% of people undergoing chemotherapy. It is reversible, but people who want to avoid it altogether can use newly developed ice caps that shunt blood flow from the head. They are not FDA approved, not covered by insurance, and so may be expensive.
6:24 Low Blood Count is a side effect of chemotherapy that can put a patient at risk of infection, and it can be prevented with an injection called Neulasta or Neupogen. It may be worth asking your physician to use it concurrently with the chemo to prevent infection.
7:05 Damage to the taste buds can be counteracted by putting ice in your mouth during the administration of the chemotherapy to shunt blood away from the taste buds. The same principle can be applied by putting your fingers on ice to help prevent fingernail damage.
7:58 A problem that is more common with weekly applications of Taxotere is that the drug can cause damage to the tear ducts. In serious cases, even scarring or closing of the tear ducts can occur. If someone undergoing chemotherapy notices increasing tearing then they need to see an eye doctor who can put a tube into the tear ducts that will allow normal drainage to occur. Ignoring this problem can cause the scarring to be permanent.
8:55 The use of chemotherapy is becoming more popular now that studies have shown that it can effectively treat High-Indigo stage (or relapsed) prostate cancer. With proper management, the side effects of chemotherapy can usually be eliminated or at least minimized to be made tolerable.
Don’t know your stage? Take the quiz: Visit http://www.prostatecancerstaging.org
To learn more about prostate cancer visit http://www.pcri.org
To download the free Staging Guide visit http://www.pcri.org/prostate-cancer-s...
Who we are:
The Prostate Cancer Research Institute (PCRI) is a 501(c)(3) not-for-profit organization that is dedicated to helping you research your treatment options. We understand that you have many questions, and we can help you find the answers that are specific to your case. All of our resources are designed by a multidisciplinary team of advocates and expert physicians, for patients. We believe that by educating yourself about the disease, you will have more productive interactions with your medical professionals and receive better-individualized care. Feel free to explore our website or call our free helpline at 1 (800) 641-7274 with any questions that you have. Our Federal Tax ID # is 95-4617875 and qualifies for maximum charitable gift deductions by individual donors.
The information on the Prostate Cancer Research Institute's YouTube channel is provided with the understanding that the Institute is not engaged in rendering medical advice or recommendation. The information provided in these videos should not replace consultations with qualified health care professionals to meet your individual medical needs.
#ProstateCancer #Prostate #MarkScholzMD
5 سال پیش
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