Crizanlizumab for the Prevention of Pain Crises in Sickle Cell Disease

Patients with sickle cell disease may experience pain crises related to P-selectin, which contributes to vaso-occlusion. Would an antibody that blocks binding to P-selectin reduce the frequency of pain crises? New research findings are summarized in this short video. Full study: www.nejm.org/doi/full/10.1056/NEJMoa1611770

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