Why Do Antidepressants Take So Long To Work?
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3 سال پیش
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Antidepressants can take anywhere from
Antidepressants can take anywhere from 2 -6 weeks to see a therapeutic effect. You may notice a little improvement sooner than that, but the usual is weeks.
There's a couple reasons for this. The first is due to the way the drug works. Medications have to reach a steady state in your body before you can get a reliable effect. It takes approximately 5 half-lives to reach steady state. If you have a medication that has a half-life of 24 hours, it takes five days to reach steady state.
A second reason has to do with the delayed effect the increase in serotonin has on your thoughts. You have the increased serotonin, then a delay, then you have the downstream neuroadaptive effects which is reducing and increasing various receptors, then you have a change in mood that causes a change in emotional bias.
A cognitive model of depression is that negative thinking both causes and perpetuates depression. When you're depressed, you have more negative view of the world. Depression affects what you pay attention to. You're more likely to notice negative facial expressions, spot negative cues in your environment and draw negative conclusions about things. This is referred to as a negative bias or negative valence.
Thoughts, feelings and behaviors are all connected. There's still a model for endogenous depression where you develop depression soley based on brain changes. But we be still believe even that depression affects your thinking. It's debatable as to which came first, depression illness or thought depressed thoughts. But the mind and the body are one. And the best approach to depression is to address them both equally. The mind approach would be through therapy or self-help measures to address your mindset and the body approach would be diet, exercise, sleep hygiene and medication if appropriate.
WANT TO START IN THERAPY? Here's a convenient and affordable option
https://Betterhelp.com/drmarks
For a monthly fee, you get a REAL licensed therapist with whom you can meet weekly by phone, video or chat. You can also send daily messages.
You have access to webinars on various topics. The unlimited texting feature allows you to type out your concerns or questions and get a well thought out response from your therapist. Some of them will help you set goals, give you worksheets, etc. If you use this link you will get a 10% discount on your first month. https://betterhelp.com/drmarks This is an option I've researched. I get a referral commission if you sign up.
References
Wilson SJ, Bell C, Coupland NJ, Nutt DJ. Sleep changes during long-term treatment of depression with fluvoxamine – a home-based study. Psychopharmacology 2000; 149: 360–5.
Harmer CJ, O'Sullivan U, Favaron E, Massey-Chase R, Ayres R, Reinecke A, Goodwin GM, Cowen PJ. Effect of acute antidepressant administration on negative affective bias in depressed patients. Am J Psychiatry. 2009 Oct;166(10):1178-84. doi: 10.1176/appi.ajp.2009.09020149. Epub 2009 Sep 15. PMID: 19755572.
Want to know more about mental health and self-improvement? On this channel I discuss topics such as bipolar disorder, major depression, anxiety disorders, attention deficit disorder (ADHD), relationships and personal development/self-improvement. I upload weekly. If you don't want to miss a video, click here to subscribe. https://goo.gl/DFfT33
Disclaimer: All of the information on this channel is for educational purposes and not intended to be specific/personal medical advice from me to you. Watching the videos or getting answers to comments/question, does not establish a doctor-patient relationship. If you have your own doctor, perhaps these videos can help prepare you for your discussion with your doctor.
There's a couple reasons for this. The first is due to the way the drug works. Medications have to reach a steady state in your body before you can get a reliable effect. It takes approximately 5 half-lives to reach steady state. If you have a medication that has a half-life of 24 hours, it takes five days to reach steady state.
A second reason has to do with the delayed effect the increase in serotonin has on your thoughts. You have the increased serotonin, then a delay, then you have the downstream neuroadaptive effects which is reducing and increasing various receptors, then you have a change in mood that causes a change in emotional bias.
A cognitive model of depression is that negative thinking both causes and perpetuates depression. When you're depressed, you have more negative view of the world. Depression affects what you pay attention to. You're more likely to notice negative facial expressions, spot negative cues in your environment and draw negative conclusions about things. This is referred to as a negative bias or negative valence.
Thoughts, feelings and behaviors are all connected. There's still a model for endogenous depression where you develop depression soley based on brain changes. But we be still believe even that depression affects your thinking. It's debatable as to which came first, depression illness or thought depressed thoughts. But the mind and the body are one. And the best approach to depression is to address them both equally. The mind approach would be through therapy or self-help measures to address your mindset and the body approach would be diet, exercise, sleep hygiene and medication if appropriate.
WANT TO START IN THERAPY? Here's a convenient and affordable option
https://Betterhelp.com/drmarks
For a monthly fee, you get a REAL licensed therapist with whom you can meet weekly by phone, video or chat. You can also send daily messages.
You have access to webinars on various topics. The unlimited texting feature allows you to type out your concerns or questions and get a well thought out response from your therapist. Some of them will help you set goals, give you worksheets, etc. If you use this link you will get a 10% discount on your first month. https://betterhelp.com/drmarks This is an option I've researched. I get a referral commission if you sign up.
References
Wilson SJ, Bell C, Coupland NJ, Nutt DJ. Sleep changes during long-term treatment of depression with fluvoxamine – a home-based study. Psychopharmacology 2000; 149: 360–5.
Harmer CJ, O'Sullivan U, Favaron E, Massey-Chase R, Ayres R, Reinecke A, Goodwin GM, Cowen PJ. Effect of acute antidepressant administration on negative affective bias in depressed patients. Am J Psychiatry. 2009 Oct;166(10):1178-84. doi: 10.1176/appi.ajp.2009.09020149. Epub 2009 Sep 15. PMID: 19755572.
Want to know more about mental health and self-improvement? On this channel I discuss topics such as bipolar disorder, major depression, anxiety disorders, attention deficit disorder (ADHD), relationships and personal development/self-improvement. I upload weekly. If you don't want to miss a video, click here to subscribe. https://goo.gl/DFfT33
Disclaimer: All of the information on this channel is for educational purposes and not intended to be specific/personal medical advice from me to you. Watching the videos or getting answers to comments/question, does not establish a doctor-patient relationship. If you have your own doctor, perhaps these videos can help prepare you for your discussion with your doctor.
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