Anti-obesity medication

This is a brief video on pharmacologic agents that help reduce weight or control weight.

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ADDITIONAL TAGS:
Anti-obesity medication
Pharmacological agents that reduce weight or help control weight
Phentermine
Orlistat
Phentermine/
topiramate
Lorcaserin
Bupropion/
naltrexone
Liraglutide
By James Heilman, MD - Own work, CC BY-SA 3.0, https://commons.wikimedia.org/w/index...

Phentermine
Approved by FDA in 1959
Mechanism: releases norepinephrine
Short term use (3 to 6 months)
Not approved for long term use
Cheap
Phentermine
Orlistat
Phentermine/
topiramate
Lorcaserin
Bupropion/
naltrexone
Liraglutide

Orlistat
Approved by FDA in 1999
Mechanism: inhibits lipase (gastric and pancreatic)
Therefore, decrease in fat breakdown and absorption
Side effects: GI disturbance (cramps, fecal incontinence, diarrhea (specifically steatorrhea)), fat soluble vitamin deficiency (vitamins DEAK) → give multivitamins
Good for CAD patients or those at risk for CVD
Available over-the-counter
Phentermine
Orlistat
Phentermine/
topiramate
Lorcaserin
Bupropion/
naltrexone
Liraglutide

Phentermine/topiramate
Approved by FDA in 2010
Phentermine mechanism: releases norepinephrine
Topiramate mechanism: blocks Na channels, modulates GABA receptor to increase action
Used for migraine prophylaxis and seizures (simple, complex, tonic-clonic)
Side effects: mental sedation, kidney stones
Phentermine
Orlistat
Phentermine/
topiramate
Lorcaserin
Bupropion/
naltrexone
Liraglutide

Lorcaserin
Approved by FDA in 2012
Mechanism: agonists serotonin (5-HT2C) receptor
Side effects: dizziness, dry mouth, GI disturbance (nausea, vomiting, diarrhea), fatigue, headaches
Phentermine
Orlistat
Phentermine/
topiramate
Lorcaserin
Bupropion/
naltrexone
Liraglutide

Bupropion/naltrexone
Approved by FDA in 2014
Bupropion mechanism: increase norepinephrine and dopamine levels
Naltrexone mechanism: opioid antagonist
Side effects: anxiety, headaches
Good for patients also struggling with smoking cessation (bupropion approved for smoking cessation)
Phentermine
Orlistat
Phentermine/
topiramate
Lorcaserin
Bupropion/
naltrexone
Liraglutide

Liraglutide
Approved by FDA in 2015
Mechanism: agonizes the GLP-1 receptor (GLP-1 analog)
Subcutaneous injection
Side effects: pancreatitis, nausea, vomiting
Phentermine
Orlistat
Phentermine/
topiramate
Lorcaserin
Bupropion/
naltrexone
Liraglutide