Can You eat Fruit on Keto? YES! Here's When You Should
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Can You eat Fruit on Keto? YES! Here's When You Should
Insulin Variations Study - BMC Medical Genomics
This study found that you start your day with insulin sensitive muscles and insulin resistant adipose tissue, which reverses its trend towards the night, when you end up with the opposite
The showed that the diurnal effect dominates the transcriptome of the human adipose tissue, with more than 25% of the transcribed genes being diurnally regulated
The circadian gene, PER1, was prominent among the genes with significantly higher expression in the morning versus the afternoon or evening, with up to a 10-fold change in some patients for PER1 mRNA expression
Genes that were positively correlated with PER1 mRNA levels included those involved in fructose and mannose metabolism and glycolysis (PFKFB, FUK, MPI, PFKM):
A number of genes encode enzymes in glucose, mannose and fructose metabolism (PFKFB3, FUK, MPI, PFKM), with high expression levels in the morning and a decline in the afternoon through the evening, following the trend of PER1
Conversely, "fuel accumulation" genes, such as those involved in cholesterol biosynthesis (HMGCR, HMGSC1), LDL receptor (LDLR), and glucose transport (GLUTS 1, 3, 5 and 14) have low levels in the morning and rise in the afternoon (negatively, correlated with PER1 mRNA.)
Moreover, the results demonstrated robust regulation of the core clock gene, PER1, and of genes encoding for ribosome processing and biogenesis and inflammatory processes
Ribosome biogenesis genes were on the diurnal incline, with levels rising by afternoon and remaining constant until evening
Ribosome biogenesis is an indicator of cellular activity and, in this case, most likely driven by the AKT/PI3K/mTOR pathway
Fasting
This study also looked at the effect of fasting on diurnal rhythm as well (from 9pm to Noon the next day)
Found that fasting actually causes a temporal delay in the diurnal rhythm, thereby extending the catabolic state of the adipose (into the afternoon)
In other words, genes that were upregulated in the fasting arm were positively correlated with PER1 expression
https://bmcmedgenomics.biomedcentral....
That’s why it makes sense to eat fat heavy and calorie rich meals earlier in the day for breakfast and lunch
Your body tends to oxidize fats for energy more during the day, and it’s primed more for storing them later in the evening
Fructose Genes
Fructose 6-phosphate (sometimes called the Neuberg ester) is a derivative of fructose, which has been phosphorylated at the 6-hydroxy group
The great majority of glucose and fructose is converted to fructose 6-phosphate upon entering a cell
MPI
Mannose-6 phosphate isomerase (MPI), alternately phosphomannose isomerase (PMI) is an enzyme which facilitates the interconversion of fructose 6-phosphate (F6P)
The PFKM gene provides instructions for making one piece (the PFKM subunit) of an enzyme called phosphofructokinase
Specifically, the enzyme converts fructose-6-phosphate to a molecule called fructose 1,6-bisphosphate (just further along the conversion path to ultimately being stored)
GLUT5
As the study stated, "fuel accumulation" genes, such as those involved in glucose & fructose transport (GLUTS 1, 3, 5 and 14) have low levels in the morning and rise in the afternoon
GLUT5 is a fructose transporter expressed on the apical border of enterocytes in the small intestine
GLUT5 allows for fructose to be transported from the intestinal lumen into the enterocyte by facilitated diffusion due to fructose's high concentration in the intestinal lumen
Resources
1)https://bmcmedgenomics.biomedcentral....
2)https://ghr.nlm.nih.gov/gene/PFKM
Get MY groceries at MY price with Thrive Market: http://ThriveMarket.com/ThomasDeLauer
My Website: http://ThomasDeLauer.com
Can You eat Fruit on Keto? YES! Here's When You Should
Insulin Variations Study - BMC Medical Genomics
This study found that you start your day with insulin sensitive muscles and insulin resistant adipose tissue, which reverses its trend towards the night, when you end up with the opposite
The showed that the diurnal effect dominates the transcriptome of the human adipose tissue, with more than 25% of the transcribed genes being diurnally regulated
The circadian gene, PER1, was prominent among the genes with significantly higher expression in the morning versus the afternoon or evening, with up to a 10-fold change in some patients for PER1 mRNA expression
Genes that were positively correlated with PER1 mRNA levels included those involved in fructose and mannose metabolism and glycolysis (PFKFB, FUK, MPI, PFKM):
A number of genes encode enzymes in glucose, mannose and fructose metabolism (PFKFB3, FUK, MPI, PFKM), with high expression levels in the morning and a decline in the afternoon through the evening, following the trend of PER1
Conversely, "fuel accumulation" genes, such as those involved in cholesterol biosynthesis (HMGCR, HMGSC1), LDL receptor (LDLR), and glucose transport (GLUTS 1, 3, 5 and 14) have low levels in the morning and rise in the afternoon (negatively, correlated with PER1 mRNA.)
Moreover, the results demonstrated robust regulation of the core clock gene, PER1, and of genes encoding for ribosome processing and biogenesis and inflammatory processes
Ribosome biogenesis genes were on the diurnal incline, with levels rising by afternoon and remaining constant until evening
Ribosome biogenesis is an indicator of cellular activity and, in this case, most likely driven by the AKT/PI3K/mTOR pathway
Fasting
This study also looked at the effect of fasting on diurnal rhythm as well (from 9pm to Noon the next day)
Found that fasting actually causes a temporal delay in the diurnal rhythm, thereby extending the catabolic state of the adipose (into the afternoon)
In other words, genes that were upregulated in the fasting arm were positively correlated with PER1 expression
https://bmcmedgenomics.biomedcentral....
That’s why it makes sense to eat fat heavy and calorie rich meals earlier in the day for breakfast and lunch
Your body tends to oxidize fats for energy more during the day, and it’s primed more for storing them later in the evening
Fructose Genes
Fructose 6-phosphate (sometimes called the Neuberg ester) is a derivative of fructose, which has been phosphorylated at the 6-hydroxy group
The great majority of glucose and fructose is converted to fructose 6-phosphate upon entering a cell
MPI
Mannose-6 phosphate isomerase (MPI), alternately phosphomannose isomerase (PMI) is an enzyme which facilitates the interconversion of fructose 6-phosphate (F6P)
The PFKM gene provides instructions for making one piece (the PFKM subunit) of an enzyme called phosphofructokinase
Specifically, the enzyme converts fructose-6-phosphate to a molecule called fructose 1,6-bisphosphate (just further along the conversion path to ultimately being stored)
GLUT5
As the study stated, "fuel accumulation" genes, such as those involved in glucose & fructose transport (GLUTS 1, 3, 5 and 14) have low levels in the morning and rise in the afternoon
GLUT5 is a fructose transporter expressed on the apical border of enterocytes in the small intestine
GLUT5 allows for fructose to be transported from the intestinal lumen into the enterocyte by facilitated diffusion due to fructose's high concentration in the intestinal lumen
Resources
1)https://bmcmedgenomics.biomedcentral....
2)https://ghr.nlm.nih.gov/gene/PFKM
5 سال پیش
در تاریخ 1398/05/05 منتشر شده
است.
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