WVU Rockefeller Neuroscience Institute – Using Focused Ultrasound for Treating Alzheimer’s Disease
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7 ماه پیش
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A potential advancement in the
A potential advancement in the treatment of Alzheimer’s disease was announced by researchers at the West Virginia University Rockefeller Neuroscience Institute (RNI). A first in-human study demonstrates that focused ultrasound in combination with anti-amyloid-beta monoclonal antibody treatment can accelerate the clearance of amyloid-beta plaques in the brains of patients with Alzheimer’s disease.
Anti-amyloid-beta (Aβ) monoclonal antibody therapies, such as aduncaumab, lecanemab, and donanemab, can reduce amyloid-beta plaques and slow the progression of Alzheimer’s. Until now, these promising antibody therapies had limitations in reaching the brain due to the blood-brain barrier (BBB), a protective barrier between blood vessels and the brain that blocks harmful substances from getting into the brain, but also limits the access of therapeutics. More than 98 percent of drugs do not readily cross the BBB, thus requiring systemic treatments with higher doses and more frequent therapies.
RNI scientists used a focused ultrasound (FUS) system to safely and temporarily open the BBB to allow the anti-amyloid-beta antibodies increased access to targeted areas of the brain. The FUS MRI-guided treatment helmet with more than 1,000 ultrasound transducers were directed to specific brain regions with high amyloid-beta plaques.
In this first-in-human proof-of-concept study, three patients (two male and one female, aged 59-77) with mild Alzheimer’s disease received six standard monthly infusions of aducanumab antibody, immediately followed by FUS-mediated BBB opening in regions with high amyloid-beta plaques. The results demonstrated the safety of this approach and increased reduction of amyloid-beta plaques measured by PET scans.
Read more about this here: Newsroom - Rockefeller Neuroscience Institute (wvumedicine.org)
Anti-amyloid-beta (Aβ) monoclonal antibody therapies, such as aduncaumab, lecanemab, and donanemab, can reduce amyloid-beta plaques and slow the progression of Alzheimer’s. Until now, these promising antibody therapies had limitations in reaching the brain due to the blood-brain barrier (BBB), a protective barrier between blood vessels and the brain that blocks harmful substances from getting into the brain, but also limits the access of therapeutics. More than 98 percent of drugs do not readily cross the BBB, thus requiring systemic treatments with higher doses and more frequent therapies.
RNI scientists used a focused ultrasound (FUS) system to safely and temporarily open the BBB to allow the anti-amyloid-beta antibodies increased access to targeted areas of the brain. The FUS MRI-guided treatment helmet with more than 1,000 ultrasound transducers were directed to specific brain regions with high amyloid-beta plaques.
In this first-in-human proof-of-concept study, three patients (two male and one female, aged 59-77) with mild Alzheimer’s disease received six standard monthly infusions of aducanumab antibody, immediately followed by FUS-mediated BBB opening in regions with high amyloid-beta plaques. The results demonstrated the safety of this approach and increased reduction of amyloid-beta plaques measured by PET scans.
Read more about this here: Newsroom - Rockefeller Neuroscience Institute (wvumedicine.org)
7 ماه پیش
در تاریخ 1402/10/20 منتشر شده
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