The Nitric Oxide Signaling Pathway

In this University of Virginia program, Ferid Murad, winner of the 1998 Nobel Prize in physiology, discusses his research into nitric oxide, some of its many biological effects, and its application in drug development for numerous diseases. He and two other researchers earned their 1998 Nobel Prize for discoveries during the 1980s concerning nitric oxide as a signaling molecule in the cardiovascular system, and how the molecule serves to relax blood vessels. The work initiated a new chapter in several areas of biomedical research and initiated new therapies for the treatment and diagnosis of heart disease and other serious inflammatory diseases.