Amphetamine Psychosis

Amphetamine can cause psychosis. The psychosis fades quickly for some. But for others, it can persist for weeks or months, or longer. This lecture explores the mechanisms of amphetamine-related psychosis and the implications for treatment.

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📘 Chapters 📘
0:00 Amphetamine can cause psychosis
1:02 Chemical structure of amphetamine and derivatives
2:37 The difference between amphetamine and methamphetamine
3:36 MDMA (Ecstasy) links to amphetamine
4:25 What does amphetamine do?
5:47 The first amphetamine epidemic
6:52 The new amphetamine epidemic
8:10 Amphetamine can cause psychosis
9:06 The dopamine hypothesis of psychosis
10:32 Different patterns of amphetamine-related psychosis
12:10 Having an episode of substance-induced psychosis is linked to higher risk of later developing schizophrenia or bipolar disorder
13:32 Definition of substance-induced psychosis
15:33 Does amphetamine just ‘pull forward’ latent genetic risk?
16:55 Amphetamine-related persisting psychosis has a different pattern of medication response
18:00 Amphetamine-related persisting psychosis might involve free radical damage
19:57 Amphetamine can activate brain inflammation signals
20:56 Angiotensin receptors may be involved in amphetamine-induced inflammation signaling
21:43 Animal studies suggest benefits from angiotensin receptor blockers
22:23 Case reports of minocycline for amphetamine-induced psychosis
26:24 Risks associated with minocycline