Vitamin K (menaquinone) Biosynthesis
389 بار بازدید -
4 سال پیش
-
The biosynthesis of vitamin K
The biosynthesis of vitamin K (menaquinone) from molecules produced in the shikimate pathway and the polyprenyl pyrophosphates.
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References and Resources:
Vitamin K Fact Sheet: https://ods.od.nih.gov/factsheets/Vit...
Vitamin K Biosynthesis Mechanisms: https://www.enzyme-database.org/react...
Biosynthesis of Menaquinone (Vitamin K2) and Ubiquinone (Coenzyme Q): https://www.ncbi.nlm.nih.gov/pmc/arti...
Lysine 190 Is the Catalytic Base in MenF, the Menaquinone-Specific Isochorismate Synthase from Escherichia coli: Implications for an Enzyme Family: https://pubs.acs.org/doi/10.1021/bi06...
An Open and Shut Case: The Interaction of Magnesium with MST Enzymes: https://pubs.acs.org/doi/pdf/10.1021/...
MenF Mechanism: https://www.ebi.ac.uk/thornton-srv/m-...
An isochorismate hydroxymutase isogene in Escherichia coli: https://febs.onlinelibrary.wiley.com/...
Molecular Basis of the General Base Catalysis of an / -Hydrolase Catalytic Triad: https://www.researchgate.net/publicat...
Vitamin K2 in Electron Transport System: Are Enzymes Involved in Vitamin K2 Biosynthesis Promising Drug Targets? https://www.mdpi.com/1420-3049/15/3/1...
Host-pathogen biotic interactions shaped vitamin K metabolism in Archaeplastida: https://www.nature.com/articles/s4159...
Evolution of Enzymatic Activity in the Enolase Superfamily: Structural Studies of the Promiscuouso-Succinylbenzoate Synthase from Amycolatopsis: https://biochem.wisc.edu/sites/defaul...
Evolution of Enzymatic Activities in the Enolase Superfamily: N-Succinylamino Acid Racemase and a New Pathway for the Irreversible Conversion of D-to L-Amino Acids: https://www.chem.tamu.edu/rgroup/raus...
o-Succinylbenzoyl-CoA (OSB-CoA) synthetase (MenE): https://www.jbc.org/content/early/201...
Structural Basis of the Induced-Fit Mechanism of 1,4-Dihydroxy-2-Naphthoyl Coenzyme A Synthase from the Crotonase Fold Superfamily: https://www.ncbi.nlm.nih.gov/pmc/arti...
Crystal Structures of E. coli Native MenH and Two Active Site Mutants: https://journals.plos.org/plosone/art...
Crystal Structure of Mycobacterium tuberculosis MenB, a Key Enzyme in Vitamin K2 Biosynthesis: https://www.jbc.org/content/278/43/42...
Menaquinone biosynthesis inhibition: a review of advancements toward a new antibiotic mechanism: https://pubs.rsc.org/en/content/artic...
Chorismate Biosynthesis: http://www.bioinfo.org.cn/book/bioche...
Lysine221 is the general base residue of the isochorismate synthase from Pseudomonas aeruginosa (PchA) in a reaction that is diffusion limited: https://www.ncbi.nlm.nih.gov/pmc/arti...
Unraveling the structure and mechanism of the MST(ery) enzymes: https://www.ncbi.nlm.nih.gov/pmc/arti...
Structural Views along the Mycobacterium tuberculosis MenD Reaction Pathway Illuminate Key Aspects of Thiamin Diphosphate-Dependent Enzyme Mechanisms: https://www.cell.com/structure/pdfExt...
PDB Codes:
5JZD – MenF Isochorismate Synthase
2EUA – MenF Isochorismate Synthase
5ESU – MenD SEPHCHC Synthase
5ESO – MenD SEPHCHC Synthase
4MYD – MenH 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1-carboxylate Synthase
4MXD – MenH 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1-carboxylate Synthase
1FHV – MenC O-Succinylbenzoate Synthase
1R6W – MenC O-Succinylbenzoate Synthase
1SJA – MenC O-Succinylbenzoate Synthase
5X8F – MenE O-Succinylbenzoyl-CoA (OSB-CoA) Synthetase
4QIJ – MenB 1,4-dihydroxy-2-naphthoyl-CoA Synthase
Other places you can find content from me:
Blog - The Cynical Philosopher
https://authortomharper.com/
Twitter - @AuthorTomHarper
Twitter: AuthorTomHarper
Amazon - Author Profile
https://www.amazon.com/Thomas-Harper/...
My science fiction series available on Amazon
Incarnate: Existence
Incarnate: Essence
Incarnate: Schism
References and Resources:
Vitamin K Fact Sheet: https://ods.od.nih.gov/factsheets/Vit...
Vitamin K Biosynthesis Mechanisms: https://www.enzyme-database.org/react...
Biosynthesis of Menaquinone (Vitamin K2) and Ubiquinone (Coenzyme Q): https://www.ncbi.nlm.nih.gov/pmc/arti...
Lysine 190 Is the Catalytic Base in MenF, the Menaquinone-Specific Isochorismate Synthase from Escherichia coli: Implications for an Enzyme Family: https://pubs.acs.org/doi/10.1021/bi06...
An Open and Shut Case: The Interaction of Magnesium with MST Enzymes: https://pubs.acs.org/doi/pdf/10.1021/...
MenF Mechanism: https://www.ebi.ac.uk/thornton-srv/m-...
An isochorismate hydroxymutase isogene in Escherichia coli: https://febs.onlinelibrary.wiley.com/...
Molecular Basis of the General Base Catalysis of an / -Hydrolase Catalytic Triad: https://www.researchgate.net/publicat...
Vitamin K2 in Electron Transport System: Are Enzymes Involved in Vitamin K2 Biosynthesis Promising Drug Targets? https://www.mdpi.com/1420-3049/15/3/1...
Host-pathogen biotic interactions shaped vitamin K metabolism in Archaeplastida: https://www.nature.com/articles/s4159...
Evolution of Enzymatic Activity in the Enolase Superfamily: Structural Studies of the Promiscuouso-Succinylbenzoate Synthase from Amycolatopsis: https://biochem.wisc.edu/sites/defaul...
Evolution of Enzymatic Activities in the Enolase Superfamily: N-Succinylamino Acid Racemase and a New Pathway for the Irreversible Conversion of D-to L-Amino Acids: https://www.chem.tamu.edu/rgroup/raus...
o-Succinylbenzoyl-CoA (OSB-CoA) synthetase (MenE): https://www.jbc.org/content/early/201...
Structural Basis of the Induced-Fit Mechanism of 1,4-Dihydroxy-2-Naphthoyl Coenzyme A Synthase from the Crotonase Fold Superfamily: https://www.ncbi.nlm.nih.gov/pmc/arti...
Crystal Structures of E. coli Native MenH and Two Active Site Mutants: https://journals.plos.org/plosone/art...
Crystal Structure of Mycobacterium tuberculosis MenB, a Key Enzyme in Vitamin K2 Biosynthesis: https://www.jbc.org/content/278/43/42...
Menaquinone biosynthesis inhibition: a review of advancements toward a new antibiotic mechanism: https://pubs.rsc.org/en/content/artic...
Chorismate Biosynthesis: http://www.bioinfo.org.cn/book/bioche...
Lysine221 is the general base residue of the isochorismate synthase from Pseudomonas aeruginosa (PchA) in a reaction that is diffusion limited: https://www.ncbi.nlm.nih.gov/pmc/arti...
Unraveling the structure and mechanism of the MST(ery) enzymes: https://www.ncbi.nlm.nih.gov/pmc/arti...
Structural Views along the Mycobacterium tuberculosis MenD Reaction Pathway Illuminate Key Aspects of Thiamin Diphosphate-Dependent Enzyme Mechanisms: https://www.cell.com/structure/pdfExt...
PDB Codes:
5JZD – MenF Isochorismate Synthase
2EUA – MenF Isochorismate Synthase
5ESU – MenD SEPHCHC Synthase
5ESO – MenD SEPHCHC Synthase
4MYD – MenH 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1-carboxylate Synthase
4MXD – MenH 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1-carboxylate Synthase
1FHV – MenC O-Succinylbenzoate Synthase
1R6W – MenC O-Succinylbenzoate Synthase
1SJA – MenC O-Succinylbenzoate Synthase
5X8F – MenE O-Succinylbenzoyl-CoA (OSB-CoA) Synthetase
4QIJ – MenB 1,4-dihydroxy-2-naphthoyl-CoA Synthase
4 سال پیش
در تاریخ 1399/09/16 منتشر شده
است.
389
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