Everything you need to know about Lp(a) | ft. Dr. Tom Dayspring
71.3 هزار بار بازدید -
2 سال پیش
-
Lipoprotein(a) or Lp(a) raises risk
Lipoprotein(a) or Lp(a) raises risk of heart disease in 1 out of 5 people, yet few have heard of it. We cover all you need to know about Lp(a).
Today we take a look at lp(a). Dr. Tom Dayspring goes over what is lp(a) and why it raises cardiovascular risk.
Cholesterol travels in lipoproteins. LDL and HDL. low density lipoprotein and HDL high density lipoprotein
LDLs carry ApoB, a protein that wraps around the LDL. we can measure ApoB, it equals number of lipoproteins in that family
We can measure the content of lipoproteins, lipid panel contains LDL-cholesterol=how much cholesterol is carried in LDL lipoproteins
lp(a) is a type of LDL. lp(a) is an exception. most ApoB-carrying lipoproteins are equally atherogenic. Small LDLs, large LDLs, VLDLs. lp(a) is an outlier
most of us have low lp(a). genetically determined. ~20% have high lp(a)
tests of lp(a). we can measure number of lp(a) lipoproteins (nmol/L) or mass (in mg/dL)
Everyone should measure lp(a) once. lp(a) raises cardiovascular risk
high lp(a): managing other risk factors: healthy diet, physical activity, body weight, not smoking, blood pressure, diabetes and apoB
70% lower risk in people with high lp(a) when lifestyle and risk factors under control
statins dont lower lp(a) but statins lower risk in people with high lp(a)
PCSK9 inhibitors lower lp(a) by 25-30%
New meds in development. Reduce lp(a) by 80%
saturated fat lowers lp(a) but raises ApoB. other studies show reduction of lp(a) on lower saturated fat diets
Trans fats increase lp(a) but most are banned from the market in the US
no diet demonstrated for lp(a) specifically but diet can help with risk factors like ApoB and BP
Summary: measure lp(a) once
References:
https://jamanetwork.com/journals/jama...
https://pubmed.ncbi.nlm.nih.gov/31147...
https://www.sciencedirect.com/science...
https://academic.oup.com/eurheartj/ar...
https://www.atherosclerosis-journal.c...
https://www.sciencedirect.com/science...
https://www.ncbi.nlm.nih.gov/pmc/arti...
Peter Attia´s podcast: 210 - Lp(a) and its impact on heart d...
Disclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.
#NutritionMadeSimple #GilCarvalho
0:00 Introduction
1:51 Overview. Lipoproteins & lp(a)
3:10 What is lp(a)
4:26 lp(a) raises cardiovascular risk
6:41 How to measure lp(a)
11:17 Other risks
12:45 Management
20:02 Nutrition
21:40 Summary and resources
Today we take a look at lp(a). Dr. Tom Dayspring goes over what is lp(a) and why it raises cardiovascular risk.
Cholesterol travels in lipoproteins. LDL and HDL. low density lipoprotein and HDL high density lipoprotein
LDLs carry ApoB, a protein that wraps around the LDL. we can measure ApoB, it equals number of lipoproteins in that family
We can measure the content of lipoproteins, lipid panel contains LDL-cholesterol=how much cholesterol is carried in LDL lipoproteins
lp(a) is a type of LDL. lp(a) is an exception. most ApoB-carrying lipoproteins are equally atherogenic. Small LDLs, large LDLs, VLDLs. lp(a) is an outlier
most of us have low lp(a). genetically determined. ~20% have high lp(a)
tests of lp(a). we can measure number of lp(a) lipoproteins (nmol/L) or mass (in mg/dL)
Everyone should measure lp(a) once. lp(a) raises cardiovascular risk
high lp(a): managing other risk factors: healthy diet, physical activity, body weight, not smoking, blood pressure, diabetes and apoB
70% lower risk in people with high lp(a) when lifestyle and risk factors under control
statins dont lower lp(a) but statins lower risk in people with high lp(a)
PCSK9 inhibitors lower lp(a) by 25-30%
New meds in development. Reduce lp(a) by 80%
saturated fat lowers lp(a) but raises ApoB. other studies show reduction of lp(a) on lower saturated fat diets
Trans fats increase lp(a) but most are banned from the market in the US
no diet demonstrated for lp(a) specifically but diet can help with risk factors like ApoB and BP
Summary: measure lp(a) once
References:
https://jamanetwork.com/journals/jama...
https://pubmed.ncbi.nlm.nih.gov/31147...
https://www.sciencedirect.com/science...
https://academic.oup.com/eurheartj/ar...
https://www.atherosclerosis-journal.c...
https://www.sciencedirect.com/science...
https://www.ncbi.nlm.nih.gov/pmc/arti...
Peter Attia´s podcast: 210 - Lp(a) and its impact on heart d...
Disclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.
#NutritionMadeSimple #GilCarvalho
0:00 Introduction
1:51 Overview. Lipoproteins & lp(a)
3:10 What is lp(a)
4:26 lp(a) raises cardiovascular risk
6:41 How to measure lp(a)
11:17 Other risks
12:45 Management
20:02 Nutrition
21:40 Summary and resources
2 سال پیش
در تاریخ 1401/05/31 منتشر شده
است.
71,382
بـار بازدید شده