Magnetization Transfer T1 Contrast: Mechanisms, Sensing Quantifying

Nikolaus Weiskopf Magnetic resonance imaging (MRI) yields exquisite soft tissue contrast. This lecture focuses on longitudinal relaxation and magnetization transfer (MT) as contrast mechanisms. For both contrast mechanisms the basic theoretical description and definitions are introduced. It is discussed how they are affected by microstructural characteristics, particularly macromolecular content and myelination in the brain. Different acquisition and analysis methods are described for sensing and quantifying the longitudinal relaxation time (T1) and parameters of MT. Examples of the use of T1 and MT mapping in neuroimaging with a focus on myelin mapping are explored. ismrm2020

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