Neurosteroids as endogenous modulators of epileptic seizures

Dr. Giuseppe Biagini, Associate Professor of Physiology at the Department of Biomedical, Metabolic and Neural Sciences of the University of Modena and Reggio Emilia (Italy). Abstract: Neurosteroids are a family of steroidal molecules which produce a variety of biological effects, mainly by interacting with the γ-aminobutyric acid receptor A (GABAA). Among neurosteroids, allopregnanolone and tetrahydrodeoxycorticosterone are positive modulators of GABAA receptors which were shown to counteract se

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